Theories and evidence for chemical biopoieses
Extremophiles 2002 -- Rossi et al. 185 (13): 3683 -- The Journal of Bacteriology: "most molecules with essential biological functions, such as nucleotides, some amino acids, and nucleic acids, are thermolabile. Miller's 'primitive soup' hypothesis, implying that the first living organisms used RNA as the information molecule, has been challenged by the 'metabolic life ' theory. This hypothesis suggests that primordial 'life' was nothing other than a series of self-catalyzed reactions based on simple compounds such as CO2 and CO. Since many reactions are thermodynamically more favorable at high temperatures, it has been suggested that hydrothermal environments were the cradle of this 'metabolic life.' "